| 摘要 |
PCT No. PCT/US97/09832 Sec. 371 Date Oct. 27, 1998 Sec. 102(e) Date Oct. 27, 1998 PCT Filed Jun. 10, 1997 PCT Pub. No. WO97/48706 PCT Pub. Date Dec. 24, 1997This invention relates to pyrrolo[1,2-a]pyrazine-1,4-diones of general formula: wherein B is carbonyl or methylene, R2, R4, R5, and R6 are hydrogen, alkyl, or substituted alkyl, A is a basic group, and Q is hydrogen or a keto heterocycle group. The compounds are inhibitors of serine proteases, typically thrombin, Factor Xa, and Factor VIIa, and are useful for treating and preventing thrombotic disorders.
|
