| 摘要 |
PCT No. PCT/FR96/00547 Sec. 371 Date Mar. 3, 1997 Sec. 102(e) Date Mar. 3, 1997 PCT Filed Apr. 11, 1996 PCT Pub. No. WO96/32102 PCT Pub. Date Oct. 17, 1996A cationic amphipathic compound of formula (I), wherein A is a single bond, an NH-R' grouping or (a), wherein -R'- is a straight or branched, optionally substituted, saturated or unsaturated C1-22 aliphatic chain optionally interrupted by one or more O, S or N heteroatoms and one or more saturated, unsaturated or aromatic carbocyclic or heterocyclic radicals; each of R1, R2 and R3, which are the same or different, is a higher acyl or alkyl grouping; each of R7, R8 and R9, which are the same or different, is a (CH2)n alkylene radical where 1</=N</=6; each of R4, R5 and R6, which are the same or different, is a hydrogen atom or an optionally substituted C1-22 alkyl, alkenyl, alkynyl or acyl radical optionally interrupted by one or more heteroatoms selected from), S and N, or one or more saturated, unsaturated or aromatic carbocyclic or heterocyclic radicals, or else at least two of the groupings R4, R5 and R6, taken together with the nitrogen atom to which they are attached, form a quinuclidino, piperidino, pyrrolidino or morpholino grouping, and X is a non-toxic anion. For use as a drug, a transfection agent or an additive in a vaccine composition.
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