发明名称 |
PROCESS FOR THE PREPARATION OF 9-DEAZAGUANINE DERIVATIVES |
摘要 |
PURPOSE: Process for the preparation of 9-deazaguanine derivatives is provided. CONSTITUTION: Derivatives of 9-deazaguanine are prepared by reacting an aldehyde or ketone with a dialkylaminomalonate to form the corresponding enamine. The enamine is then reacted with a base to form a cyclic pyrrole. The cyclic pyrrole is reacted with an urea compound to provide a protected guanidino compound. The guanidino is converted to the desired 9-deazaguanine derivative by reacting with trifluoracetic acid or with an alkoxide or hydroxide followed by neutralization with an acid.
|
申请公布号 |
KR20000057547(A) |
申请公布日期 |
2000.09.25 |
申请号 |
KR19997005268 |
申请日期 |
1999.06.11 |
申请人 |
BIOCRYST PHARMACEUTICALS, INC. |
发明人 |
ELLIOTT ARTHUR J;WALSH DAVID A;MORIS PHILIP E |
分类号 |
C07D487/04;(IPC1-7):C07D487/04 |
主分类号 |
C07D487/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|