VACCINE FOR THE REVERSIBLE IMMUNOCASTRATION OF MAMMALS

摘要

PURPOSE: A peptide derived from GnRH for the immunocastration of mammals is used in the field of Genetic Engineering and Biotechnology. CONSTITUTION: A peptide derived from GnRH for the immunocastration of mammals is provided. Vaccinations tests have been carried out in mammals with the gonadotropin release hormone (GnRH), in order to ellicit and immune response which neutralizes to activity of said hormone. Also, provided is the use of a GnRH variant of mammals wherein a glycine residue has been substituted by a prolin residue in position 6: Glu-His-Trp-Ser-Tyr-Pro-Leu-Arg-Pro-Gly. This substitution or change has induced an immune response which is superior than that of natural GnRH, when both are coupled to a same carrier protein, in experiments carried out in pigs. This same result can be expected in any other mammal since this hormone is present in all species.