发明名称 |
A NOVEL COMPLEX OF HUMAN KALLIKREIN 2 (hK2) AND PROTEASE INHIBITOR-6 (PI-6) IN PROSTATE TUMOR TISSUE AND METHODS OF USING THE COMPLEX |
摘要 |
The present invention provides a novel complex of hK2 and PI-6 and methods of using the novel complex. The novel complexes of hK2 and PI-6 of the present invention exist at an elevated level in prostat cancer tissues. Therefore, the hK2-PI6 complexes of the present invention may be used as a serum marker for detecting prostate cancer. They may also be used as an immunohistological marker to detect prostate cancer tissues. In accordance with the present invention, the hK2-PI6 complexes of the present invention may be detected in patient tissue samples by immunohistochemical and/or in patient fluid samples by in vitro immunoassay procedures. Diagnostic kits and diagnostic methods for detecting the existence of prostate cancer are also provided.
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申请公布号 |
WO0055308(A1) |
申请公布日期 |
2000.09.21 |
申请号 |
WO2000US01937 |
申请日期 |
2000.01.26 |
申请人 |
HYBRITECH INCORPORATED |
发明人 |
MIKOLAJCZYK, STEPHEN;SAEDI, MOHAMMAD |
分类号 |
G01N33/53;C07K14/81;C07K16/38;C07K16/40;C12N9/64;C12N9/99;C12P21/08;C12Q1/37;G01N33/573;G01N33/577;(IPC1-7):C12N9/64;G01N33/574;G01N33/68 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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