ENHANCED GAMMA-CARBOXYLATION OF RECOMBINANT VITAMIN K-DEPENDENT CLOTTING FACTORS
摘要
The invention relates to methods of optimizing gamma carboxylation of a vitamin K-dependent protein, methods of generating fully gamma carboxylated vitamin K-dependent protein, and compositions comprising chimeric nucleic acids and proteins for use in treatment of vitamin K-dependent disease states.
申请公布号
WO0054787(A1)
申请公布日期
2000.09.21
申请号
WO2000US06934
申请日期
2000.03.16
申请人
THE CHILDREN'S HOSPITAL OF PHILADELPHIA;UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
发明人
HIGH, KATHERINE, A.;CAMIRE, RODNEY, M.;LARSON, PETER, J.;STAFFORD, DARREL, W.
