发明名称 |
SUBSTITUTED 1-OXO- AND 1,3-DIOXOISOINDOLINES AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR REDUCING INFLAMMATORY CYTOKINE LEVELS |
摘要 |
1-Oxo- and 1,3-dioxoisoindolines substituted in the 4- or 5-position of the indoline ring reduce the levels of inflammatory cytokines such as TNF alpha in a mammal. A typical embodiment is 4-(4-amino-1,3-dioxoisoindolin-2-yl)-4-carbamoylbutanoic acid. |
申请公布号 |
WO0055134(A1) |
申请公布日期 |
2000.09.21 |
申请号 |
WO2000US07029 |
申请日期 |
2000.03.17 |
申请人 |
CELGENE CORPORATION;MULLER, GEORGE, W.;STIRLING, DAVID |
发明人 |
MULLER, GEORGE, W.;STIRLING, DAVID |
分类号 |
A61K31/4035;A61P35/00;A61P37/00;A61P37/04;A61P43/00;C07D209/46;C07D209/48 |
主分类号 |
A61K31/4035 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|