Assay for emetic activity

摘要

An assay for emetic activity among inhibitors of type 4 phosphodiesterase (PDE 4) is disclosed. The assay comprises:(A) administering to a test mammal an anesthetic compound in an amount sufficient to cause an anesthetic effect;(B) administering to the test mammal a test compound that has PDE 4 inhibitory activity;(C) observing the test mammal for changes in the anesthetic effect, and(D) correlating any change in the anesthetic effect observed in the anesthetized test mammal to a standard.