发明名称 |
COMBINED THERAPY WITH A CHEMOTHERAPEUTIC AGENT AND AN ONCOLYTIC VIRUS FOR KILLING TUMOR CELLS IN A SUBJECT |
摘要 |
The invention includes methods, compositions, and kits for killing tumor cells in a subject such as a human patient. The methods comprise administering both a chemotherapeutic agent and an oncolytic virus other than an adenovirus to a subject which has tumor cells. The agent and virus exhibit oncolytic activities that are at least additive, and that may be synergetic. The oncolytic virus may, for example, be a herpes simplex virus (type 1 or 2), a vaccinia virus, a vesicular stomatitis virus, or a Newcastle desease virus. The compositions and kits comprise a chemotherapeutic agent and an oncolytic virus other than an adenovirus, either in admixture or separately. |
申请公布号 |
WO0054795(A1) |
申请公布日期 |
2000.09.21 |
申请号 |
WO1999US05536 |
申请日期 |
1999.03.15 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;MOLNAR-KIMBER, KATHERINE;TOYOIZUMI, TAKANE;KAISER, LARRY |
发明人 |
MOLNAR-KIMBER, KATHERINE;TOYOIZUMI, TAKANE;KAISER, LARRY |
分类号 |
A61K35/76;A61K38/20;A61K38/21;A61K45/06;(IPC1-7):A61K38/00;A61K39/395;A01N63/00;C07K1/00 |
主分类号 |
A61K35/76 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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