FUNCTIONALLY ASSEMBLED ANTIGEN-SPECIFIC INTACT RECOMBINANT ANTIBODY AND A METHOD FOR PRODUCTION THEREOF

摘要

Functionally assembled antigen-specific intact recombinant monoclonal antibody produced by transformation of the methylotropic yeast, P. pastoris with mouse/human immunoglobulin genes encoding heavy and light chains. A method for production of the intact monoclonal antibodies, a recombinant yeast expression vector and the antibody-specific mRNA synthesis. A process for a large-scale production of the functionally assembled intact recombinant antibody.