| 摘要 |
It has been surprisingly discovered that the disadvantages of the lengthy procedures previously known to synthesize 13,14-dihydro prostaglandin A, D, E, and F derivatives can be overcome using a novel C1, C9, and C11-protected 7-(5-(3-oxopropyl)-2,4-dihydroxy-cyclopentyl) heptanoic acid intermediate, which can be synthesized from commercially available Methyl 7-[3-(R)-hydroxy-5-oxo-1-cyclopent-1-yl] heptanoate. This novel intermediate can be coupled with carbon nucleophiles in the presence of a base to provide 13,14-dihydro prostaglandin A, D, E, and F derivatives. |
