| 摘要 |
Methods and systems for animal models of herpes simplex virus infections, for use in drug discovery, drug testing and research. Includes models of cutaneous herpes simplex viral infections, with reactivation by use of ultraviolet radiation. Following induction and resolution of primary infection, a drug to be tested is administered prior or subsequent to reactivation by use of ultraviolet radiation, including solar spectral radiation, to determine effectiveness of the drug to inhibit or limit reactivation infection. Also provided are methods for determining effectiveness of drugs to inhibit or limit primary infections, and methods for determining effectiveness of drugs, including topical preparations, as sunscreen agents, including ultraviolet-B specific radiation agents. |
