发明名称 |
Auf HERV-LTR-Sequenzen basierende retrovirale Expressionsvektoren |
摘要 |
The invention relates to retroviral expression vectors with cell-specifically modulatable promotors. The vectors can be used, for example, for the cell-specific expression of therapeutically valuable genes in gene therapy. The invention specifically relates to retroviral expression vectors containing at least the following elements, in a functional configuration: a) DNA sequences for the packaging of the vector RNA and for the cell-specific expression of proteins or peptides which are coded by heterologous DNA nucleotide sequences; b) one or more DNA nucleotide sequences coding for a protein or a peptide and characterized in that for cell-specific expression said DNA sequences contain a cell-specifically modulatable promotor region of a human endogenous retroviral DNA nucleotide sequence (HERV).
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申请公布号 |
DE19910650(A1) |
申请公布日期 |
2000.09.21 |
申请号 |
DE19991010650 |
申请日期 |
1999.03.10 |
申请人 |
GSF-FORSCHUNGSZENTRUM FUER UMWELT UND GESUNDHEIT GMBH |
发明人 |
LEIB-MOESCH, CHRISTINE;SCHOEN, ULRIKE;BAUST, CORINNA |
分类号 |
C12N7/01;C12N15/867;(IPC1-7):C12N15/867 |
主分类号 |
C12N7/01 |
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地址 |
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