The present invention is a process for the preparation of a compound of formula (VIII) where R3, R4 and n are defined in the specification which comprises hydrogenating a compound of formula (VII) the E-geometrical isomer thereof or a mixture of the Z- and E-isomers in the presence of catalyst containing Rh, a chiral ligand with at least one phosphorous atom where the hydrogenation is conducted in the presence of a base.
申请公布号
WO0055150(A1)
申请公布日期
2000.09.21
申请号
WO2000US03720
申请日期
2000.03.14
申请人
PHARMACIA & UPJOHN COMPANY;HEWITT, BRADLEY, D.;BURK, MARK, J.;JOHNSON, NICHOLAS, B.
发明人
HEWITT, BRADLEY, D.;BURK, MARK, J.;JOHNSON, NICHOLAS, B.