| 发明名称 |
Inhibitors of prenyl-protein transferase |
| 摘要 |
The present invention comprises piperazine/piperazinone-containing compounds having multicyclic ring system substituents on one of the piperazine/piperazinone nitrogens, which inhibit prenyl-protein transferases, including farnesyl-protein transferase and geranylgeranyl-protein transferase type I. Such therapeutic compounds are useful in the treatment of cancer. |
| 申请公布号 |
AU4005300(A) |
申请公布日期 |
2000.09.21 |
| 申请号 |
AU20000040053 |
申请日期 |
2000.03.02 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
WILLIAM C. LUMMA;ANTHONY M SMITH;JOHN T. SISKO |
| 分类号 |
C12N9/99;A61K31/454;A61P1/16;A61P9/10;A61P13/12;A61P27/02;A61P31/10;A61P31/12;A61P35/00;A61P35/02;A61P43/00;C07D233/54;C07D233/64;C07D401/06;C07D403/06 |
主分类号 |
C12N9/99 |
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