| 摘要 |
<p>A method of inhibiting the self-splicing of a Group I intron is disclosed. The method uses an oligonucleotide having a sequence essentially identical to a guide sequence found in the 5' flanking exon and terminates with a 3' ribonucleoside. Usually the oligonucleotide has N3'→P5' phosphoramidate or N3'→P5' thiophosphoramidate linkages rather than phosphodiester linkages. A method of inhibiting the growth of organisms having Group I intron, particularly certain pathogenic fungi including P. carinii, C. albicans and A. nidulans using the oligonucleotide is also provided.</p> |
