| 发明名称 |
ASYMMETRIC SYNTHESIS OF (-) 6-CHLORO-4-CYCLOPROPYL-ETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE |
| 摘要 |
<p>An improved synthesis of a highly potent HIV reverse transcription inhibitor is disclosed, involving an acetylide and a trifluoromethyl ketone which produces a chiral product in the presence of a chiral amino alcohol.</p> |
| 申请公布号 |
EP0828703(B1) |
申请公布日期 |
2000.09.20 |
| 申请号 |
EP19960920322 |
申请日期 |
1996.05.21 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
THOMPSON, ANDREW, S.;CORLEY, EDWARD, G.;GRABOWSKI, EDWARD, J., J.;YASUDA, NOBUYOSHI |
| 分类号 |
C07B53/00;C07C213/00;C07C215/68;C07C215/70;C07C217/58;C07D265/18;(IPC1-7):C07C213/00 |
主分类号 |
C07B53/00 |
| 代理机构 |
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| 地址 |
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