发明名称 |
Process for the manufacture of an 18F-labelled glycosylation reagent as well as 18F-glycosylation reagent and its use |
摘要 |
<p>An <18>F-labelled glycosylating agent is prepared by: (a) reaction of a hexose (I) with phosphoric acid (H3PO4); (b) hydrolysis of the product with a base; and (c) reaction of the product with uridine triphosphate (UTP) in the presence of pyrophosphorylase and Mg<2+>. Preparation of an <18>F-labelled glycosylating agent comprises: (a) reaction of a hexose of formula (I) with phosphoric acid (H3PO4); (b) hydrolysis of the product with a base; and (c) reaction of the product with uridine triphosphate (UTP) in the presence of a phosphorylase and Mg<2+>. one group R = <18>F in position 2, 3, 4 or 6 of the hexose ring, and the other three = a protecting group which is linked to the hexose ring via an oxygen atom An Independent claim is included for a glycosylating reagent of formula (II): one group R' = <18>F in position 2, 3, 4 or 6 of the hexose ring, and the other three R' groups = OH; OUDP = a uridine diphosphate group</p> |
申请公布号 |
EP1034797(A3) |
申请公布日期 |
2000.09.20 |
申请号 |
EP20000103937 |
申请日期 |
2000.02.25 |
申请人 |
FORSCHUNGSZENTRUM JUELICH GMBH |
发明人 |
PRANTE, OLAF;HAMACHER, KURT, DR.;COENEN, HEINZ H., PROF. |
分类号 |
A61K51/04;C07H3/02;(IPC1-7):A61K51/04 |
主分类号 |
A61K51/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|