摘要 |
PCT No. PCT/HU97/00027 Sec. 371 Date Apr. 2, 1999 Sec. 102(e) Date Apr. 2, 1999 PCT Filed Jun. 5, 1997 PCT Pub. No. WO97/46523 PCT Pub. Date Dec. 11, 1997This invention relates to peptide aldehyde derivatives of formula (I): D-Xaa-Pro-Arg-H, wherein Xaa represent a 2-cycloheptyl-2-hydroxyacetyl or 2-cyclopentyl-2-hydroxyacetyl group, Pro represents an L-prolyl residue and Arg represents an L-arginyl residue, their acid-additon salts formed with an organic or inorganic acid and pharmaceutical compositions containing the same. The compounds of formula (I) of the invention have therapeutic, particularly anticoagulant, antiplatelet and antithrombotic properties.
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申请人 |
GYOGYSZERKUTATO INTEZET KFT. |
发明人 |
BAJUSZ, SANDOR;JUHASZ, ATTILA;BARABAS, EVA;FEHER, ANDRAS;SZABO, GABRIELLA;SZELL NEE HASENOEHRL, ERZSEBET;VEGHELYI NEE FAUSZT, IREN;LAVICH NEE OSZKO, EMILIA;KASZAS, EVA;LANGO, JOZSEF;MORAVCSIK, IMRE;SZEKER NEE PESZEKY, AGNES;TASCHLER NEE PASZTOR, ZSUZSANNA;TOTH, GABOR;MOHAI NEE NAGY, ZSUZSANNA;SZALKAY NEE HOLLOSI, ANNA MARIA;MAKK NEE OCSKAY, KLARA |