Epiligrin, an epithelial ligand for integrins

摘要

PCT No. PCT/US94/10261 Sec. 371 Date Feb. 22, 1996 Sec. 102(e) Date Feb. 22, 1996 PCT Filed Sep. 2, 1994 PCT Pub. No. WO95/06660 PCT Pub. Date Mar. 9, 1995Nucleic acid sequences are disclosed encoding an E170 epithelial ligand and capable of hybridizing under stringent conditions to the nucleotide sequences derived from cDNA clones shown in the figure. Also disclosed are vectors containing the nucleic acid sequences, and cells transformed with the vectors. Methods are given for purifying and utilizing epiligrin, an epithelial glycoprotein complex, and its component glycoproteins, and for raising antibodies against components of this complex. Assay methods are further provided for identification of functional epiligrin in tissues.