| 摘要 |
PCT No. PCT/EP97/02244 Sec. 371 Date Oct. 6, 1998 Sec. 102(e) Date Oct. 6, 1998 PCT Filed May 2, 1997 PCT Pub. No. WO97/43290 PCT Pub. Date Nov. 20, 1997The present invention relates to camptothecin-skeleton alkaloids isolated from Mappia foetida or obtained by semi-synthesis from said alkaloids. Mappia foetida, a plant growing in the Indian subcontinent, is known to contain in its various parts, mainly in the seeds, camptothecin, mappicine and foetidine I and II (EP-A-685481). The alkaloids of the invention have the following general formula: in which R is a hydrogen atom or a methoxy group; R1 is hydroxy, an OM group wherein M is an alkali cation, preferably sodium or potassium, a C1-C6 alkoxy group, an optionally substituted phenoxy group, an amino, C1-C6 monoalkylamino or C2-C12 dialkylamino group in which the alkyl moiety is optionally substituted by amino groups, an arylamino group; R2 is a C1-C6 alkyl group or a group of formula COR3 wherein R3 is alkyl C1-C6 or optionally substituted phenyl or benzyl.
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