| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new cyclic tetrapeptide derivative having promoting action on the MHC Class-I molecule expression in a self-tissue cell and useful as an anticancer agent, or the like. SOLUTION: The objective compound is expressed by formulas I-IV (R11, R12, R21 and R22 are each H, a non-aromatic cycloalkyl, a 1-6C straight-chain alkyl, a 3-6C branched alkyl, or the like; R1 to R3 are each a 1-5C straight-chain alkylene which may have a 1-6C branched chain on the chain and the branched chain forms a condensed ring structure on the alkylene chain; at least one of R11, R12, R21 and R22 of formula IV is cyclohexylmethyl), e.g. cyclo (-L-Asu(NHOH)-Acc5-L-Phe-D-Pro-). The compounds of formulas I to IV are producible e.g. by converting a chain tetrapeptide intermediate into a cyclic tetrapeptide and finally inducing the side-chain carboxyl group of anα-amino acid represents by formula V into hydroxamic acid structure.
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