| 摘要 |
PURPOSE: An artificial blood vessel is provided which is advantageous in that the material therefor is easily available, that the application to a living body causes no significant rejection, that a suture can be held after implantation for a long period of time, and that, after a given period of time, it can be entirely or partially absorbed into the living body and decomposed. CONSTITUTION: A artificial blood vessel comprises a tube made of a supporting skeletal material and a collagen layer(2) of ultrafine fibers provided at least outside the tube, and a process for preparing the same. This vessel is produced by (1) impregnating a tube composed of a supporting framework material with collagen and drying; (2) freezing a collagen acidic solution at least on the outside of this tube followed by freeze-drying to form a collagen layer composed of ultra-fine fibers; (3) compressing the collagen-coated tube obtained in this manner; (4) additionally impregnating the tube obtained in step (3) with collagen and drying; (5) thermal crosslinking the tube obtained in step (4); and (6) coating the lumen of the tube with a matrix gel.
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