BIS-IMIDE DERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND DIESE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNG

摘要

Bis-imides of formula (I), their isomers and salts are new. m, n = 0 or 1; X, Y = H, halo, 1-6C alkyl, 1-6C trihaloalkyl, 1-6C alkoxy, OH, CN, NO2, amino, alkylamino, or dialkylamino; Z = 4-12C alkylene chain optionally interrupted by groups NR, O, S, SO, SO2, CONH, or an optionally substituted heterocycle; R = H or 1-6C alkyl; A, with two adjacent C atoms of the phenyl ring to which it is attached, forms one of the following groups, all of which may be substituted: phenyl, naphthyl, tetrahydronaphthyl, 1,4-dioxo-1,2,3,4-tetrahydronaphthyl, or a heterocycle; the ring containing B forms a group of formula (i) or (ii); m1, n1, X1, Y1, and A1 are as defined for m, n, X, Y, and A respectively; and X2 and Y2 are as defined for X and Y.