ARYL AND HETEROARYL SUBSTITUTED FUSED PYRROLE ANTIINFLAMMATORY AGENTS

摘要

PURPOSE: Provided is a new class of novel aryl and heteroaryl substituted fused pyrrole compounds useful for the prophylaxis and treatment of diseases or conditions, such as TNF-α, IL-1β, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. CONSTITUTION: A compound of formula or a pharmacutically acceptable salt thereof is represented, wherein X1 is N, CH or CR1; X2 is N, CH or CR2; X3 is N, CH or CR3; and X4 is N, CH or CR4; provided that at least one of X1, X2, X3 and X4 is N or CH, and that not more than two of X1, X2, X3 and X4 are N; wherein R1, R2, R3 and R4 are each independently -Z-Y, provided that (1) R2 and R4 are not both substituted or unsubstituted amino radicals; (2) the total number of aryl, heteroaryl, cycloalkyl and heterocyclyl radicals in each -Z-Y is 0-3; and (3) the combined total number of aryl, heteroaryl, cycloalkyl and heterocyclyl radicals in R1, R2, R3 and R4 is 0-4.