| 摘要 |
PURPOSE: A present invention relates to a novel fine cisplatin powder utilized as an anticancer agent. The fine cisplatin powder obtained in the present invention does not cause secondary agglomeration, is excellent in fluidity and easily handleable in the pharmaceutical preparation step. Furthermore, the fine cisplatin powder is reduced in the content of N,N-dimethylformamide as the residual solvent, and can be dissolved rapidly in physiological saline, thus being suitable for cancer therapy particularly by intra-arterial injection. This fine powder can be produced by contriving specified means for crystallizing cisplatin from a solution thereof in N,N-dimethylformamide. CONSTITUTION: A fine cisplatin powder consisting substantially of a fine cisplatin powder passing through a 40-mesh screen, wherein when a fine powder consisting of these finely divided particles is placed on a 40-mesh screen and subjected to a screen passage test (vibration at 50 r.p.s. for 5 minutes with a vibration strength of 4.6 G), the percentage of the secondarily agglomerated particles remaining on the screen is 10 % or less.
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