| 摘要 |
PURPOSE: Prepared is a pharmaceutical composition comprising a water-insoluble medicinally active substance, surfactant(s) and solid carrier(s), which has very satisfactory dissolution property, oral absorbability and so on. The pharmaceutical composition of the present invention can be used in the field of medical care. CONSTITUTION: A pharmaceutical composition is characterized in that the water-insoluble medicinally active substance is a tricyclic compound (I) of the following general formula or a pharmacologically acceptable salt thereof. (wherein each of adjacent pairs of R¬1 and R¬2, R¬3 and R¬4 or R¬5 and R¬6 independently (a) is two adjacent hydrogen atoms, or (b) may form another bond formed between the carbon atoms to which they are attached, and further, R¬2 may be an alkyl group; R¬7 is a hydrogen atom, a hydroxy group, a protected hydroxy group or an alkoxy group, or an oxo group together with R¬1; each of R¬8 and R¬9 is independently a hydrogen atom or a hydroxy group; R¬(10) is a hydrogen atom, an alkyl group, an alkyl group substituted by one or more hydroxy groups, an alkenyl group, an alkenyl group substituted by one or more hydroxy groups or an alkyl group substituted by an oxo group; X is an oxo group, (a hydrogen atom and a hydroxy group), (a hydrogen atom and a hydrogen atom), or a group represented by the formula -CH2O-; Y is an oxo group, (a hydrogen atom and a hydroxy group), (a hydrogen atom and a hydrogen atom), or a group represented by the formula N-NR¬(11)R¬(12) or N-OR¬(13); each of R¬(11) and R¬(12) is independently a hydrogen atom, an alkyl group, an aryl group or a tosyl group; each of R¬(13), R¬(14), R¬(15), R¬(16), R¬(17), R¬(18), R¬(19), R¬(22) and R¬(23) is independently a hydrogen atom or an alkyl group; each of R¬(20) and R¬(21) is independently an oxo group or (R¬(20)a and a hydrogen atom) or (R¬(21)a and a hydrogen atom) in which each of R¬20a and R¬21a is independently a hydroxy group, an alkoxy group or a group represented by the formula -OCH2OCH2CH2OCH3, or R¬21a is a protected hydroxy group, or R¬20a and R¬21a may together represent an oxygen atom in an epoxide ring; n is an integer of 1 or 2; and in addition to the above definitions, Y, R¬(10) and R¬(23), together with the carbon atoms to which they are attached, may represent a saturated or unsaturated 5- or 6-membered nitrogen, sulfur and/or oxygen containing heterocyclic ring optionally substituted by one or more groups selected from the group consisting of an alkyl, a hydroxy, an alkyl substituted by one or more hydroxy groups, an alkoxy, a benzyl and a group of the formula -CH2Se(C6H5).
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