发明名称 1,3-DIOXOLANE 2,4,4-TRISUBSTITUTED DERIVATIVES AS ANTIFUNGICIDES, A METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION BASED THEREON (VARIANTS)
摘要 The present invention concerns novel compounds of formula (I), a N-oxide form, a pharmaceutically acceptable acid addition salt or a stereochemically isomeric form thereof, wherein n is zero, 1, 2 or 3; X is N or CH; each R1 independently is halo, nitro, cyano, amino, hydroxy, C1-4alkyl, C1-4alkyloxy or trifluoromethyl; R2 is hydrogen; C3-7alkenyl; C3-7alkynyl, aryl; C3-7cycloalkyl; optionally substituted C1-6alkyl; R3 and R4 each independently are hydrogen, C1-6 alkyl, C3-7cycloalkyl or aryl; or R3 and R4 taken together form a bivalent radical -R3-R4- of formula (a), (b), (c), (d), or (e), wherein R5a, R5b, R5c, R5d each independently are hydrogen, C1-6alkyl or aryl; and aryl is optionally substituted phenyl; as antifungals; their preparation, compositions containing them and their use as a medicine. , (I)
申请公布号 UA71543(C2) 申请公布日期 2000.09.15
申请号 UA20000010162 申请日期 1998.07.07
申请人 JANSSEN PHARMACEUTICA N.V. 发明人
分类号 C07D405/06;A61K31/496;A61K31/506;A61K31/53;A61P29/00;A61P31/04;A61P31/10;C07D233/00;C07D241/00;C07D317/00;C07D405/14;C07D521/00;(IPC1-7):C07D405/06;A61K31/41;A61K31/44 主分类号 C07D405/06
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