| 摘要 |
PURPOSE: Neurotrophic low molecular weight, small molecule N-linked sulfonamides of heterocyclic thioesters having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity, are provided. CONSTITUTION: A compound of formula I, or a pharmaceutically acceptable salt thereof, are provided, wherein A and B are taken together, with the nitrogen and carbon atoms to which they are respectfully attached, to form a pyrrolidine or piperidine ring; X is either O or S, with the proviso that when A and B taken together with the nitrogen and carbon atoms to which they are attached form a piperidine ring, then X is not S; Y is a direct bond to Z, or a C1-C6 straight or branched chain alkyl or alkenyl; Z is a direct bond, or a C1-C6 straight or branched chain alkyl or alkenyl; C and D are independently; R1 is selected from the group consisting of Ar, or C3-C8 cycloalkyl, or C1-C6 straight or branched chain alkyl or alkenyl, or C1-C6 straight or branched chain alkyl or alkenyl which is substituted in one or more positions with Ar or C3-C8 cycloalkyl. |
