Treatment or prevention of amyotrophic lateral sclerosis, using synergistic combination of riluzole and AMPA receptor antagonist, e.g. 5H,10H-imidazo (1,2-a) indeno (1,2-e) pyrazin-4-one derivative

摘要

The use of a combination of riluzole (i.e. 2-amino-6-trifluoromethoxybenzothiazole) (I) (or its salt) and one or more alpha -amino-4-hydroxy-5-methyl-isoxazole-4-propionate (AMPA) receptor antagonists (II) for preparation of a medicament for the prevention and/or treatment of amyotropic lateral sclerosis (ALS) is new.