HERMANSKY PUDLAK SYNDROME PROTEIN-INTERACTING PROTEINS AND METHODS OF USE THEREOF

摘要

Provided are complexes of polypeptides which include an HPS polypeptide and an HPS-interacting polypeptides (HPSIP). The HPSIP polypeptides include 14-3-3 protein, Hrs, atrophin-1, DGS-I, nuclear factor NF90, HPIP1 and human HN1 homolog protein. Also disclosed are nucleic acids encoding the HPIP1 and human HN1 homolog protein, or derivatives, fragments and analogs thereof. Methods of screening the complexes or proteins for efficacy in treating and/or preventing certain diseases and disorders, particulary atopic diseases, autoimmune diseases, neurodegenerative disease, cancer, pigmentation disorders, platelet dysfunction and viral diseases, are also disclosed.