| 摘要 |
<p>A process for producing a quinazoline derivative represented by general formula (I) which comprises reacting a compound represented by general formula (II) with a compound represented by R3-X (III) in an appropriate solvent in the presence of an alkali metal carbonate and optionally of a small amount of water. In the formulas, R1 represents hydrogen or halogeno; R2 represents protected carboxy; R3 represents ar(lower)alkyl optionally substituted by one or more appropriate substituents; Z represents lower alkylene; and X represents an acid residue.</p> |
