A general immunoglobulin-target assay system is provided, in which a positive outcome (the generation of a signal) depends only on the intracellular interaction of immunoglobulin with target. This can be accomplished for many immunoglobulins expressed in yeast and/or in mammalian cells and allows the selection of immunoglobulins which are capable of functioning in an intracellular environment.
申请公布号
WO0054057(A1)
申请公布日期
2000.09.14
申请号
WO2000GB00876
申请日期
2000.03.10
申请人
MEDICAL RESEARCH COUNCIL;TSE, ERIC;RABBITS, TERENCE;CATTANEO, ANTONIO;VISINTIN, MICHELA