发明名称 |
MN GENE AND PROTEIN |
摘要 |
Identified herein is the location of the MN protein binding site, and MN proteins/polypeptides that compete for attachment to vertebrate cells with immobilized MN protein. Such MN proteins/polypeptides prevent cell-cell adhesion and the formation of intercellular contacts. The MN protein binding site is a therapeutic target that can be blocked by organic or inorganic molecules, preferably organic molecules, more preferably proteins/polypeptides that specifically bind to that site. Therapeutic methods for inhibiting the growth of preneoplastic/neoplastic vertebrate cells that abnormally express MN protein are disclosed. Vectors are provided that encode the variable domains of MN-specific antibodies and a flexible linker polypeptide separating those domains. Further vectors are disclosed that encode a cytotoxic protein/polypeptide operatively linked to the MN gene promoter, and which vectors preferably further encode a cytokine. The MN gene promoter is characterized, and the binding site for a repressor of MN transcription is disclosed.
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申请公布号 |
WO0024913(A3) |
申请公布日期 |
2000.09.14 |
申请号 |
WO1999US24879 |
申请日期 |
1999.10.22 |
申请人 |
BAYER CORPORATION;INSTITUTE OF VIROLOGY;ZAVADA, JAN;PASTOREKOVA, SILVIA;PASTOREK, JAROMIR |
发明人 |
ZAVADA, JAN;PASTOREKOVA, SILVIA;PASTOREK, JAROMIR |
分类号 |
G01N33/566;A61K38/00;A61K39/395;A61K48/00;A61P35/00;C07K7/06;C07K14/47;C07K14/82;C12N9/88;C12N15/09;C12Q1/02;C12R1/91;(IPC1-7):C12N9/88;C07K16/40 |
主分类号 |
G01N33/566 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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