发明名称 |
NUCLEIC ACID RESPIRATORY SYNCYTIAL VIRUS VACCINES |
摘要 |
Non-replicating vectors containing a nucleotide sequence coding for an F protein of respiratory syncytial virus (RSV) and a promoter for such sequence, preferably a cytomegalovirus promoter, are described for in vivo immunization. The nucleotide sequence encoding the RSV F protein lacks a sequence encoding the homologous signal peptide but possesses a heterologous signal peptide enhancing RSV F protein expression. Such non-replicating vectors, including plasmids, also may contain a further nucleotide sequence located adjacent to the RSV F protein encoding sequence to enhance the immunoprotective ability of the RSV F protein when expressed in vivo. Such non-replicating vectors may be used to immunize a host against disease caused by infection with RSV, including a human host, by administration thereto, and may be formulated as immunogenic compositions with pharmaceutically-acceptable carriers for such purpose. Such vectors also may be used to produce antibodies for detection of RSV infection in a sample.
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申请公布号 |
WO0053767(A2) |
申请公布日期 |
2000.09.14 |
申请号 |
WO2000CA00227 |
申请日期 |
2000.03.03 |
申请人 |
CONNAUGHT LABORATORIES LIMITED;LI, XIAOMAO;EWASYSHYN, MARY, E.;SAMBHARA, SURYAPRAKASH;KLEIN, MICHEL, H. |
发明人 |
LI, XIAOMAO;EWASYSHYN, MARY, E.;SAMBHARA, SURYAPRAKASH;KLEIN, MICHEL, H. |
分类号 |
C12N15/09;A61K35/76;A61K39/00;A61K39/155;A61K39/245;A61K39/395;A61P11/00;A61P31/12;A61P31/14;A61P37/04;C07K14/135;C12N15/45;C12N15/85;(IPC1-7):C12N15/45;A61K48/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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