A process for the preparation of a compound of formula (I) or a salt thereof or a carboxylic acid ester derivative thereof, wherein L represents a leaving group, which comprises (a) treating a compound of formula (II) wherein R represents COOH or a salt thereof or a derivative thereof and L and L<1> represent leaving groups with a base such that L<1> is eliminated and the oxazole ring is formed; and (b) if necessary converting the R moiety to COOH or a salt thereof or a carboxylic acid ester derivative thereof. A further aspect of this invention is the preparation of the potassium salt of a pyrrolidinyl derivative of compound of formula (I) and coupling of the said salt to an amine.
申请公布号
WO0053589(A1)
申请公布日期
2000.09.14
申请号
WO2000GB00867
申请日期
2000.03.09
申请人
GLAXO GROUP LIMITED;CARDWELL, KEVIN, STUART;HERMITAGE, STEPHEN, ANDREW
发明人
CARDWELL, KEVIN, STUART;HERMITAGE, STEPHEN, ANDREW