发明名称 |
BIFUNCTIONAL MOLECULES FOR DELIVERY OF THERAPEUTICS |
摘要 |
A bifunctional molecule consisting of a therapeutic molecule and a ligand which specifically binds a transcytotic receptor can be transported specifically from the basolateral surface of epithelial cells to the apical surface. This approach provides the ability to deliver a therapeutic molecule directly to the apical surface of the epithelium, by targeting the transcytotic receptor with an appropriate ligand. Thus, the highest concentration of the therapeutic molecule will be at the apical surface, where it can have the greatest therapeutic effect.
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申请公布号 |
WO0053623(A1) |
申请公布日期 |
2000.09.14 |
申请号 |
WO2000US05930 |
申请日期 |
2000.03.08 |
申请人 |
CASE WESTERN RESERVE UNIVERSITY |
发明人 |
DAVIS, PAMELA, B.;FERKOL, THOMAS, W., JR.;ECKMAN, ELIZABETH |
分类号 |
A61K47/48;A61K38/00;A61K45/00;A61P31/04;C07H21/02;C07K14/52;C07K14/81;C07K16/00;C07K19/00;C12P21/04;C12Q1/68;G01N33/53;G01N33/567;(IPC1-7):C07K1/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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