METHOD FOR DETERMINING ANALYTE CONCENTRATION USING PERIODIC TEMPERATURE MODULATION AND PHASE DETECTION

摘要

A method of determining the analyte concentration of a test sample is described. A temperature gradient is introduced in the test sample (102). Infrared radiation detectors measure radiation at selected analyte absorptio n peak, and reference wavelengths (104). Reference, and analyte signals are detected. In the presence of the selected analyte, parameter differences between reference, and analytical signals are detectable. These parameter differences, having a relationship to analyte concentration, are measured, correlated, and processed to determine analyte concentration in the test sample (106). Accuracy is enhanced by inducing a periodically modulated temperature gradient in the test sample. The analytical, the reference signa ls may be measured continuously, and the parameter difference integrated over t he measurement period to determine analyte concentration.