Lovastatin fermentation by employing novel mutant strain Aspergillus terreus

摘要

A strain of Aspergillus terreuswith the temporary name GB 2033 is obtained by methods of the classic mutagenesis and archived in the Czech Republic collection of microorganisms in Brno under the name Aspergillus terreusCCM 8236. An independent claim is also included for a method of fermentation preparation of lovastatin in the form of acid or lactone or its pharmaceutically utilizable salts or esters comprising a culturing of the strain of Aspergillus terreusCCM 8236 in an inoculum broth having pH value in a range of 4.5 - 4.7 and an application of a carbon source at a form of a combination of glucose and lactose, the combination featuring 0.5 0.7% of glucose and 11 - 15% of lactose, and an application of a cotton flower or soya flower as a complex source in the production step, and at the same time the concentration of the ammonia ions is in a range 0 - 0.07 g/l. ACTIVITY : Antilipemic; MECHANISM OF ACTION : Lovastatin inhibits HMG CoA reductase.