| 摘要 |
A drug delivery molecule has a targeting moiety, coupled to a routing moiety and a bioactive molecule. The targeting moiety binds to a cell receptor without eliciting an agonistic effect and binding results in uptake of the drug delivery molecule into the cell. Contemplated drug delivery molecules may be employed for treatment and diagnosis. A method of selectively targeting an endothelial cell includes recognizing that presence or absence of somatostatin type II receptors on the endothelial cell correlates with a proximal position of the endothelial cell to an anomalous cell. Endothelial cells proximal to anomalous cells are then presented with a somatostatin type II receptor specific compound. In further methods, the presence of a somatostatin type II receptor on an endothelial cell proximal to a tissue is correlated with a disease of the tissue. In subsequent steps, somatostatin type II receptor specific compounds are administered to the endothelial cell. |
