发明名称 |
Libraries of backbone-cyclized peptidomimetics |
摘要 |
Libraries of novel backbone-cyclized peptide analogs are formed by means of bridging groups attached via the alpha nitrogens of amino acid derivatives to provide novel non-peptidic linkages. Novel building units used in the synthesis of these backbone-cyclized peptide analogs are N(((-functionalized) amino acids constructed to include a spacer and a terminal functional group. One or more of these N(((-functionalized) amino acids are incorporated into a library of peptide sequences, preferably during solid phase peptide synthesis. The reactive terminal functional groups are protected by specific protecting groups that can be selectively removed to effect either backbone-to-backbone or backbone-to-side chain cyclizations. The invention is exemplified by libraries of backbone-cyclized bradykinin analogs, somatostatin analogs, BPI analogs and Substance P analogs having biological activity. Further embodiments of the invention are Interleukin-6 receptor derived peptides having ring structures involving backbone cyclization.
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申请公布号 |
US6117974(A) |
申请公布日期 |
2000.09.12 |
申请号 |
US19950569042 |
申请日期 |
1995.12.07 |
申请人 |
PEPTOR LIMITED;YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY IN JERUSALEM |
发明人 |
GILON, CHAIM;HORNIK, VERED |
分类号 |
G01N33/566;A61K38/00;C07K1/04;C07K5/00;C07K7/22;C07K7/56;C07K14/00;C07K14/655;C07K17/02;G01R31/3185;(IPC1-7):A61K38/12;C07K1/046 |
主分类号 |
G01N33/566 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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