| 摘要 |
PROBLEM TO BE SOLVED: To obtain a strong and safe calcium antagonist useful as a therapeutic medicine for ischemic heart diseases, e.g. cardiotonic agents or cardiac infarction by including an uridine alkylphosphate compound as an active ingredient. SOLUTION: This calcium antagonist comprises an uridine 5'-alkyl phosphate compound of the formula (R is an alkyl), e.g. uridine 5'-hexadecyl phosphate an active ingredient. The compound of the formula is obtained by dissolving, e.g. uridine 5'-monophosphate and an alkyl alcohol in tert-butyl alcohol and reacting uridine 5'-monophosphate in the presence of dicyclohexylcarbodiimide usually at 60-100 deg.C for 2-20 hr. The compound of the formula can be administered by oral, parenteral, transrectal or percutaneous administration and the compound is preferably administered to each of adult patients at a daily total dose of 1-2,000 mg in the case of oral administration and 0.1-400 mg in the case of parenteral administration.
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