发明名称 |
Purification of 1,2-dihydro-6-alkyl-2-oxo-5-(pyridinyl)-nicotinonitriles |
摘要 |
The present invention comprises a process for preparing essentially pure 1,2-dihydro-6-alkyl-2-oxo-5-(pyridinyl)-nicotinonitriles from a crude reaction mixture containing the corresponding amide as an impurity. By "essentially pure" is meant a level of purity acceptable for orally administered pharmaceutical products, usually less than 0.1% of any single impurity. At least a stoichiometric amount of an acylating agent is reacted with the crude reaction mixture, and thereafter recovering essentially pure 1,2-dihydro-6-alkyl-2-oxo 5-(pyridinyl)-nicotinonitrile.
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申请公布号 |
US6118002(A) |
申请公布日期 |
2000.09.12 |
申请号 |
US19990260640 |
申请日期 |
1999.03.02 |
申请人 |
WYCKOFF CHEMICAL COMPANY, INC. |
发明人 |
VANDERROEST, JAMES M.;SPRINGER, JAMES J.;OLSEN, RICHARD S. |
分类号 |
C07D213/84;(IPC1-7):C07D401/04;C07D213/62 |
主分类号 |
C07D213/84 |
代理机构 |
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