| 发明名称 |
Recombinant vaccine made in E. coli against dengue virus |
| 摘要 |
A recombinant protein encompassing a C-terminal protion from the structural envelope glycoprotein and an N-terminal portion from non-structural protein one of dengue type 2 virus was expressed in Escherichia coli as a fusion protein with Staphylococcal protein A. The recombinant protein was found to provide protection against lethal challenge with dengue 2 in mice.
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| 申请公布号 |
US6117640(A) |
申请公布日期 |
2000.09.12 |
| 申请号 |
US19950433263 |
申请日期 |
1995.05.02 |
| 申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY |
发明人 |
SRIVASTAVA, ASHOK KUMAR;PUTNAK, J. ROBERT;HOKE, CHARLES H.;WARREN, RICHARD L. |
| 分类号 |
A61K39/00;A61P31/12;C07K14/18;C07K14/31;(IPC1-7):A61K39/12;C07H21/04 |
主分类号 |
A61K39/00 |
| 代理机构 |
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代理人 |
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| 主权项 |
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