| 摘要 |
PROBLEM TO BE SOLVED: To obtain a skin agent for external use excellent in skin care effects by bringing the agent to contain creatinine, creatine and specific active materials. SOLUTION: This skin agent for external use contains (A) creatinine (methylglycocyamidine) and/or creatine and (B) a pharmaceutically effective material and/or a biologically active material [e.g. whitening agents (e.g. ellagic acid, kojic acid, etc.), wrinkle-improving agents (e.g. pantothenic acid, vitamin A, etc.), antioxidants (e.g. pantothenic acid, arginine, etc.), circulation accelerators (nicotinic acid amide, sialid extracts, etc.), sebum control agents (e.g. oil soluble licorice extracts, rose wood extracts, etc.), pimple-preventing agents (e.g. salicylic acid, etc.), etc.]. The aforesaid agent for external use preferably contains 0.01-10 wt.% of the ingredient A and 0.001-20 wt.% of the ingredient B.
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