METHOD OF CRYSTALLIZATION OF ALPHA-L-ASPARTYL-L- PHENYLALANINE FROM AQUEOUS SOLUTION

摘要

chemical industry. SUBSTANCE: described is improved method of crystallization of alpha-L-aspartyl-L-phenylalanine methyl ether (aspartam) from aqueous solution by conductive cooling, to avoid turbulence in crystallization system where crystallization is carried out when temperature is not lower than 10 C in the presence of at least 0.1 wt % of alpha ketone, amount of ketone and temperature being selected for each individual ketone so that dohomeneous system of solvent is present as crystallization beings and open skeleton of aspartam crystals is formed. EFFECT: more efficient crystallization method. 14 cl, 2 ex, 1 tbl