The present invention comprises piperazine-containing compounds which inhibit prenyl-protein transferases. In particular, the invention relates to prenyl-protein transferase inhibitors which are efficacious in vivo as inhibitors of geranylgeranyl-protein transferase type I (GGTase-I) and that inhibit the cellular processing of both the H-Ras protein and the K4B-Ras protein. Such therapeutic compounds are useful in the treatment of cancer.
申请公布号
WO0051614(A1)
申请公布日期
2000.09.08
申请号
WO2000US05354
申请日期
2000.03.01
申请人
MERCK & CO., INC.;STUMP, CRAIG, A.;WILLIAMS, THERESA, M.
