发明名称 |
PROCESSES FOR MAKING PHARMACEUTICAL ORAL ECB FORMULATIONS AND COMPOSITIONS |
摘要 |
A fluid bed spray process is described where one or more carbohydrates are incorporated into an echinocandin formulation to provide a significant improvement in thermal stability. The carbohydrate is solubilized with an echinocandin compound or echinocandin/carbohydrate complex in a solvent(s) to form a pharmaceutical solution which is sprayed onto the surface of a granular diluent or carrier. Alternatively, a granulating agent is added to the pharmaceutical solution which is then sprayed onto the surface of a non-granular diluent or carrier. The resulting granular oral formulations and medicaments derived therefrom are also described.
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申请公布号 |
WO0051567(A1) |
申请公布日期 |
2000.09.08 |
申请号 |
WO2000US05547 |
申请日期 |
2000.03.02 |
申请人 |
ELI LILLY AND COMPANY;SCHWIER, JOHN, RICHARD;TAYLOR, JERRY |
发明人 |
SCHWIER, JOHN, RICHARD;TAYLOR, JERRY |
分类号 |
A61K9/16;A61K38/12;A61P31/10;(IPC1-7):A61K9/16 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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