| 摘要 |
The present invention provides compounds of formula (I) wherein R1 is H or benzyl; R2 is H, -OH, or -O-benzyl; R3, R4, and R5 are independently selecte d from H, halogen, cyano, C1-C6 alkyl (straight chain or branched), trifluoromethyl, -OH or the C1-C12 esters (straight chain or branched) or C1 - C12 alkyl ethers (straight chain or branched or cyclic) thereof, or C1-C6 halogenated ethers; R6 is H or C1-C6 alkyl; R7 is C1-C6 alkyl; n is 2 to 3; Y is O or S; and X is the moiety -NR'R' wherein R' is selected from C1-C6 lowe r alkyl or X is one of the moieties (A), (B), (C), or (D); or a pharmaceutical ly acceptable salt thereof, as well as pharmaceutical compositions and methods utilizing the compounds for treating or preventing disease states or syndrom es which are caused or associated with an estrogen deficiency or an excess of estrogen utilizing these compounds.
|
