| 发明名称 |
TUMOR NECROSIS FACTOR RECEPTORS 6.ALPHA. AND 6.BETA. |
| 摘要 |
The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encodi ng the human TNFR-6.alpha. and -6.beta. proteins. TNFR-6.alpha. and -6.beta. polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6.alpha. and -6.bet a. activity. Also provided are diagnostic methods for detecting immune system- related disorders and therapeutic methods for treating immune system-related disorders.
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| 申请公布号 |
CA2362929(A1) |
申请公布日期 |
2000.09.08 |
| 申请号 |
CA20002362929 |
申请日期 |
2000.03.03 |
| 申请人 |
HUMAN GENOME SCIENCES, INC. |
发明人 |
RUBEN, STEVEN M.;FENG, PING;NI, JIAN;EBNER, REINHARD;YU, GUO-LIANG;GENTZ, REINER L. |
| 分类号 |
C12N15/09;A61K35/76;A61K38/00;A61K39/395;A61K48/00;A61P1/00;A61P1/04;A61P1/16;A61P3/10;A61P5/14;A61P7/06;A61P9/00;A61P9/02;A61P9/04;A61P9/06;A61P9/08;A61P9/10;A61P9/12;A61P9/14;A61P13/12;A61P19/08;A61P19/10;A61P25/00;A61P25/16;A61P25/28;A61P27/02;A61P29/00;A61P31/04;A61P31/12;A61P31/18;A61P35/00;A61P35/02;A61P37/02;A61P37/06;A61P43/00;C07K14/715;C07K16/28;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12P21/02;C12R1/91;(IPC1-7):C12N15/28;A61K31/705;C12Q1/68;C12N15/63;C12N15/12;C12N5/06;C07H21/04;C12P21/00;C12N5/00;C07K14/00;C07K14/705 |
主分类号 |
C12N15/09 |
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